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Mol Cell. 2016 Oct 6;64(1):7-9. doi: 10.1016/j.molcel.2016.09.023.

Nick Your DNA, Mark Your Chromatin.

Author information

1
Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Großhaderner Street 9, 82152 Planegg-Martinsried, Germany.
2
Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Großhaderner Street 9, 82152 Planegg-Martinsried, Germany; Center for Integrated Protein Science Munich (CIPSM), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany. Electronic address: andreas.ladurner@med.lmu.de.

Abstract

DNA damage induces chemical and structural changes in our chromatin-embedded genome. In a recent issue of Nature Communications, Grundy et al. (2016) identify a role for PARP3 in the repair of single-strand breaks and reveal that PARP3 mono-ADP-ribosylates nucleosomal histone H2B.

PMID:
27716488
DOI:
10.1016/j.molcel.2016.09.023
[Indexed for MEDLINE]
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