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BMC Med. 2016 Oct 7;14(1):153.

Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial.

Author information

1
Department of Medicine Austin Health, University of Melbourne, 145 Studley Road, Heidelberg, VIC, 3084, Australia.
2
Department of Endocrinology, Austin Health, 300 Waterdale Road, Heidelberg West, VIC, 3081, Australia.
3
Department of Mathematics and Statistics, La Trobe University, Plenty Road & Kingsbury Drive, Melbourne, VIC, 3086, Australia.
4
Department of Medicine, School of Clinical Sciences, Monash University, Clayton Road, Clayton, VIC, 3800, Australia.
5
Department of Medicine Austin Health, University of Melbourne, 145 Studley Road, Heidelberg, VIC, 3084, Australia. mathisg@unimelb.edu.au.
6
Department of Endocrinology, Austin Health, 300 Waterdale Road, Heidelberg West, VIC, 3081, Australia. mathisg@unimelb.edu.au.

Abstract

BACKGROUND:

Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass.

METHODS:

We conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass index ≥ 30 kg/m2) with a total testosterone level of or below 12 nmol/L and a median age of 53 years (interquartile range 47-60) receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of 10-weekly intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls). The main outcome measures were the between-group difference in fat and lean mass by dual-energy X-ray absorptiometry, and visceral fat area (computed tomography).

RESULTS:

A total of 82 men completed the study. At study end, compared to controls, cases had greater reductions in fat mass, with a mean adjusted between-group difference (MAD) of -2.9 kg (-5.7 to -0.2; P = 0.04), and in visceral fat (MAD -2678 mm2; -5180 to -176; P = 0.04). Although both groups lost the same lean mass following VLED (cases -3.9 kg (-5.3 to -2.6); controls -4.8 kg (-6.2 to -3.5), P = 0.36), cases regained lean mass (3.3 kg (1.9 to 4.7), P < 0.001) during weight maintenance, in contrast to controls (0.8 kg (-0.7 to 2.3), P = 0.29) so that, at study end, cases had an attenuated reduction in lean mass compared to controls (MAD 3.4 kg (1.3 to 5.5), P = 0.002).

CONCLUSIONS:

While dieting men receiving placebo lost both fat and lean mass, the weight loss with testosterone treatment was almost exclusively due to loss of body fat.

TRIAL REGISTRATION:

clinicaltrials.gov, identifier NCT01616732 , registration date: June 8, 2012.

KEYWORDS:

Body composition; Caloric restriction; Obesity; Testosterone

PMID:
27716209
PMCID:
PMC5054608
DOI:
10.1186/s12916-016-0700-9
[Indexed for MEDLINE]
Free PMC Article

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