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J Nat Prod. 2016 Oct 28;79(10):2439-2445. Epub 2016 Oct 7.

Meroterpenoids and Chalcone-Lignoids from the Roots of Mimosa diplotricha.

Author information

1
National Research Institute of Chinese Medicine , Ministry of Health and Welfare, Taipei, Taiwan.
2
Institute of Traditional Medicine, National Yang-Ming University , Taipei, Taiwan.
3
Department of Radiation Oncology, Center of Biomedical Development, and Laboratory of Cancer Therapeutics, MacKay Memorial Hospital , Taipei, Taiwan.
4
Graduate Institute of Integrated Medicine, China Medical University , Taichung, Taiwan.

Abstract

Six new meroterpenoids, diplomeroterpenoids A-F (1-6), two new chalcone-lignoids, diplochalcolins A and B (7, 8), and 13 known compounds were isolated from the root extract of Mimosa diplotricha. Diplomeroterpenoids A-F consist of a 4H-chromen-4-one and a diterpenoid unit, and their absolute configurations were determined by X-ray crystallographic analysis. Compounds 1-3 and 5 showed potent inhibitory activity on protein farnesyl transferase, with IC50 values from 5.0 to 8.5 μM. Compound 1 showed antiproliferative activity against human hepatoblastoma HepG2 cells with a GI50 value of approximately 8.6 μM.

PMID:
27715048
DOI:
10.1021/acs.jnatprod.6b00170
[Indexed for MEDLINE]

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