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FEBS Lett. 2016 Dec;590(23):4393-4401. doi: 10.1002/1873-3468.12445. Epub 2016 Oct 23.

An updated structural classification of substrate-binding proteins.

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Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Zernike Institute for Advanced Materials, University of Groningen, The Netherlands.


Substrate-binding proteins (SBPs) play an important role in solute uptake and signal transduction. In 2010, Berntsson et al. classified the 114 organism-specific SBP structures available at that time and defined six protein clusters, based on their structural similarity. Since then, the number of unique SBP structures has increased almost fivefold, whereas the number of protein entries in the Protein Data Bank (PDB) nearly doubled. On the basis of the much larger dataset, we now subclassify the SBPs within the original clusters. Moreover, we propose a 7th cluster based on a small group of SBPs with structural features significantly different from those observed in the other proteins.


ABC transporter; membrane protein; signal transduction; solute transport; structural classification; substrate-binding protein

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