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J Clin Immunol. 2016 Nov;36(8):810-817. Epub 2016 Oct 6.

Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation.

Author information

1
CHRU Tours, Service de Pneumologie et explorations fonctionnelles respiratoires, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, F-37044, Tours Cedex, France.
2
Université François Rabelais, UMR 1100, F-37032, Tours, France.
3
INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100/EA6305, F-37032, Tours, France.
4
CHRU Tours, Groupement d'imagerie médicale, F-37044, Tours, France.
5
CHRU Tours, service d'information médicale, d'épidémiologie et d'économie de la santé, F-37044, Tours, France.
6
CHRU Tours, Service de néphrologie, F-37044, Tours, France.
7
Equipe Emergente EE1 Education Ethique Santé, Université François-Rabelais, Tours, France.
8
CHRU Tours, Service de Pneumologie et explorations fonctionnelles respiratoires, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, F-37044, Tours Cedex, France. guillel@free.fr.
9
Université François Rabelais, UMR 1100, F-37032, Tours, France. guillel@free.fr.
10
INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100/EA6305, F-37032, Tours, France. guillel@free.fr.

Abstract

PURPOSE:

Little is known about hypogammaglobulinemia (HGG) in asthma patients. No data are available on the characteristics of adult patients with asthma and HGG.

METHODS:

We conducted a retrospective monocentric study between January 2006 and December 2012. Asthma patients with a serum immunoglobulin (Ig) quantitative analysis were included and classified into two groups depending on their serum IgG concentration: presence or absence of HGG. Clinical, biological, functional, and radiologic characteristics were compared in univariate and multivariate analysis, using a logistic regression model.

RESULTS:

In univariate analysis, asthma patients with HGG (n = 25) were older (58 years old ± 18 vs 49 ± 18, p = 0.04) and more frequently active or former smokers as compared to patients with normoglobulinemia (n = 80) (56.0 vs 35.0 %, p = 0.01). Total IgE < 30 kUI/L was more frequently observed in patients with HGG (53.0 vs 18.3 %, p = 0.01). HGG asthma patients had lower fraction of exhaled nitric oxide (p = 0.02), blood eosinophilia (p = 0.0009), and presented with more severe composite score for bronchiectasis (p = 0.01). In multivariate analysis, asthma patients with HGG had increased risk of being smokers [OR = 6.11 (IC 95 % = 1.16-32.04)], having total IgE concentration < 30 kUI/L [OR = 12.87 (IC 95 % = 2.30-72.15)], and a more severe composite score of bronchiectasis [OR = 20.65 (IC 95 % = 2.13-199.74)].

CONCLUSION:

Asthma patients with HGG are older and more often tobacco smoker than asthma patients without HGG. These patients have low type-2 inflammation markers.

KEYWORDS:

asthma; hypogammaglobulinemia; immunoglobulin G; inflammation

PMID:
27714565
DOI:
10.1007/s10875-016-0335-9
[Indexed for MEDLINE]

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