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Oncoscience. 2016 Aug 28;3(7-8):203-207. doi: 10.18632/oncoscience.316. eCollection 2016.

The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression.

Xie YZ#1,2, Yang F#3, Tan W3, Li X1,4, Jiao C2, Huang R3, Yang BB4,5.

Author information

1
State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangzhou, China.
2
Guangdong Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
3
Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou, Guangdong, China.
4
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
5
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
#
Contributed equally

Abstract

To examine the role of oral Ganoderma spore oil in cardiovascular disease, we used transverse aortic constriction (TAC) in mice to model pressure overload-induced cardiomyopathy. Our preliminary results demonstrated a potential cardioprotective role for spore oil extracted from Ganoderma. We found that Ganoderma treatment normalized ejection fraction and corrected the fractional shortening generated by TAC. We also found evidence of reduced left ventricular hypertrophy as assessed by left ventricular end diastolic diameter. Analysis of total RNA expression using cardiac tissue samples from these mice corroborated our findings. We found reduced expression of genes associated with heart failure, including a novel circular RNA circ-Foxo3. Thus our data provides evidence for Ganoderma lucidum as a potential cardioprotective agent, warranting further preclinical exploration.

KEYWORDS:

Ganoderma lucidum; anti-cancer; circular RNA; heart function; herbal medicine

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