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Pharmaceuticals (Basel). 2010 Jul 19;3(7):2248-2267.

Emerging Families of Ion Channels Involved in Urinary Bladder Nociception.

Author information

1
Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi 409-3898, Japan. iaraki@yamanashi.ac.jp.
2
Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan. iaraki@yamanashi.ac.jp.
3
Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi 409-3898, Japan. pxn15164@nifty.ne.jp.
4
Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi 409-3898, Japan. hidekik@yamanashi.ac.jp.
5
Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi 409-3898, Japan. tsutomu@yamanashi.ac.jp.
6
Department of Urology, the 1st Affiliated Hospital, China Medical University, Shenyang, China. du_shuqi@hotmail.com.
7
Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan. saki@belle.shiga-med.ac.jp.
8
Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi 409-3898, Japan. matakeda@yamanashi.ac.jp.

Abstract

The expression of multiple ion channels and receptors is essential for nociceptors to detect noxious stimuli of a thermal, mechanical or chemical nature. The peripheral sensory transduction systems of the urinary bladder include sensory nerve endings, urothelial cells and others whose location is suitable for transducing mechanical and chemical stimuli. There is an increasing body of evidence implicating the Deg/ENaC and TRP channel families in the control of bladder afferent excitability under physiological and pathological conditions. Pharmacological interventions targeting these ion channels may provide a new strategy for the treatment of pathological bladder sensation and pain.

KEYWORDS:

ion channel; nociception; sensation; transient receptor potential; urinary bladder

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