Photodynamic micelles for amyloid β degradation and aggregation inhibition

Junying Zhang; Jianping Liu; Yingying Zhu; Zhiai Xu; Jie Xu; Tingting Wang; Haijun Yu; Wen Zhang

doi:10.1039/c6cc06175c

Photodynamic micelles for amyloid β degradation and aggregation inhibition

Chem Commun (Camb). 2016 Oct 4;52(81):12044-12047. doi: 10.1039/c6cc06175c.

Authors

Junying Zhang¹, Jianping Liu², Yingying Zhu¹, Zhiai Xu¹, Jie Xu¹, Tingting Wang², Haijun Yu², Wen Zhang¹

Affiliations

¹ School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China. zaxu@chem.ecnu.edu.cn wzhang@chem.ecnu.edu.cn.
² Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

PMID: 27711295
DOI: 10.1039/c6cc06175c

Abstract

Polymeric micelles loaded with chlorin e6 and Tanshinone I (TAS) were prepared and employed for photodegrading amyloid β (Aβ) aggregates and inhibiting Aβ fibrillation.

MeSH terms

Abietanes / chemistry
Amyloid beta-Peptides / chemistry*
Amyloid beta-Peptides / metabolism*
Chlorophyllides
Micelles*
Models, Molecular
Photochemotherapy*
Polymers / chemistry
Polymers / pharmacology*
Porphyrins / chemistry
Protein Aggregates / radiation effects*
Proteolysis / radiation effects*

Substances

Abietanes
Amyloid beta-Peptides
Chlorophyllides
Micelles
Polymers
Porphyrins
Protein Aggregates
tanshinone
phytochlorin