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J Lipid Res. 2016 Dec;57(12):2208-2216. Epub 2016 Oct 5.

Monoacylglycerol-enriched oil increases EPA/DHA delivery to circulatory system in humans with induced lipid malabsorption conditions.

Author information

1
Nestlé Research Center, 1000 Lausanne, Switzerland cristina.cruz-hernandez@rdls.nestle.com.
2
Nestlé Research Center, 1000 Lausanne, Switzerland.
3
Department of Physiology, Faculty of Biology and Medicine, 1005 Lausanne, Switzerland.
4
University of Lausanne, 1005 Lausanne, Switzerland.

Abstract

It was hypothesized that under induced lipid malabsorption/maldigestion conditions, an enriched sn-1(3)-monoacylglycerol (MAG) oil may be a better carrier for n-3 long-chain PUFAs (LC-PUFAs) compared with triacylglycerol (TAG) from fish oil. This monocentric double blinded clinical trial examined the accretion of EPA (500 mg/day) and DHA (300 mg/day) when consumed as TAG or MAG, into the erythrocytes, plasma, and chylomicrons of 45 obese (BMI ≥30 kg/m2 and ≤40 kg/m2) volunteers who were and were not administered Orlistat, an inhibitor of pancreatic lipases. Intake of MAG-enriched oil resulted in higher accretion of LC-PUFAs than with TAG, the concentrations of EPA and DHA in erythrocytes being, respectively, 72 and 24% higher at 21 days (P < 0.001). In addition, MAG increased the plasma concentration of EPA by 56% (P < 0.001) as compared with TAG. In chylomicrons, MAG intake yielded higher levels of EPA with the area under the curve (0-10 h) of EPA being 55% greater (P = 0.012). In conclusion, in obese human subjects with Orlistat-induced lipid maldigestion/malabsorption conditions, LC-PUFA MAG oil increased LC-PUFA levels in erythrocytes, plasma, and chylomicrons to a greater extent than TAG. These results indicate that MAG oil might require minimal enzymatic digestion prior to intestinal uptake and transfer across the epithelial barrier.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01797757.

KEYWORDS:

Orlistat; clinical trials; diet effects/lipid metabolism; digestion; docosahexaenoic acid; eicosapentaenoic acid; fatty acid/metabolism; lipase; lipid absorption; obese; polyunsaturated fatty acid

PMID:
27707818
PMCID:
PMC5321218
DOI:
10.1194/jlr.P070144
[Indexed for MEDLINE]
Free PMC Article

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