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Lancet. 2016 Oct 1;388(10052):1437-1446. doi: 10.1016/S0140-6736(16)31458-1.

Pathophysiology, research challenges, and clinical management of smoke inhalation injury.

Author information

1
Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: peenkhba@utmb.edu.
2
Department of Surgery, Division of Trauma, University of Texas Health Science Center, San Antonio, TX, USA.
3
Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA; Shriners Hospitals for Children, Galveston, TX, USA.
4
Shriners Hospitals for Children, Galveston, TX, USA; Department of Respiratory Care, School of Health Professions, University of Texas Medical Branch, Galveston, TX, USA.
5
Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, TX, USA.
6
Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Abstract

Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.

PMID:
27707500
PMCID:
PMC5241273
DOI:
10.1016/S0140-6736(16)31458-1
[Indexed for MEDLINE]
Free PMC Article

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