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PLoS One. 2016 Oct 5;11(10):e0164039. doi: 10.1371/journal.pone.0164039. eCollection 2016.

Longitudinal Lung Function Decrease in Subjects with Spontaneous Healed Pulmonary Tuberculosis.

Author information

1
Division of Pulmonary, Sleep, and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
2
Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Republic of Korea.

Abstract

OBJECTIVE:

We compared the longitudinal course of post-bronchodilator Forced Expiratory Volume in 1 second (pFEV1) over a 10-year period in subjects with spontaneous healed pulmonary tuberculosis (SHPTB) with that in normal subjects.

METHODS:

We prospectively investigated 339 subjects with SHPTB and 3211 normal subjects. pFEV1 values measured biannually over 10 years were analyzed using mixed effects model.

RESULTS:

At baseline, there were no differences in gender, smoking amount, and mean height, except mean age (50.0 ± 8.1 VS. 48.1 ± 7.3, P< 0.001) between the SHPTB and normal group. 52% of the 339 participants with SHPTB and 56% of the 3211 normal participants participated till the end of study. According to the final model, the SHPTB group showed significantly larger decrease in the average pFEV1 over the time than the normal group (P< 0.001) adjusted for gender, age, height, smoking pack years, and time effects. Especially, the interaction effect between time and group was statistically significant (P = 0.036).

CONCLUSION:

The average lung function in terms of pFEV1 decreases faster in subjects with SHPTB than in normal individuals over time.

PMID:
27706203
PMCID:
PMC5051937
DOI:
10.1371/journal.pone.0164039
[Indexed for MEDLINE]
Free PMC Article

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