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Viruses. 2016 Oct 3;8(10). pii: E270.

Zoonotic Hepatitis E Virus: Classification, Animal Reservoirs and Transmission Routes.

Doceul V1,2,3, Bagdassarian E4,5,6, Demange A7,8,9, Pavio N10,11,12.

Author information

1
French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Animal Health Laboratory, UMR (joint research unit) 1161 Virology, 94701 Maisons-Alfort, France. virginie.doceul@vet-alfort.fr.
2
French National Institute for Agricultural Research (INRA), UMR (joint research unit) 1161 Virology, 94700 Maisons-Alfort, France. virginie.doceul@vet-alfort.fr.
3
Association of Universities and High Education Institutions (ComUE), Paris-Est Créteil Val-de-Marne University, National Veterinary School, UMR (joint research unit) 1161 Virology, 94700 Maisons-Alfort, France. virginie.doceul@vet-alfort.fr.
4
French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Animal Health Laboratory, UMR (joint research unit) 1161 Virology, 94701 Maisons-Alfort, France. eugenie.bagdassarian@vet-alfort.fr.
5
French National Institute for Agricultural Research (INRA), UMR (joint research unit) 1161 Virology, 94700 Maisons-Alfort, France. eugenie.bagdassarian@vet-alfort.fr.
6
Association of Universities and High Education Institutions (ComUE), Paris-Est Créteil Val-de-Marne University, National Veterinary School, UMR (joint research unit) 1161 Virology, 94700 Maisons-Alfort, France. eugenie.bagdassarian@vet-alfort.fr.
7
French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Animal Health Laboratory, UMR (joint research unit) 1161 Virology, 94701 Maisons-Alfort, France. antonin.demange@vet-alfort.fr.
8
French National Institute for Agricultural Research (INRA), UMR (joint research unit) 1161 Virology, 94700 Maisons-Alfort, France. antonin.demange@vet-alfort.fr.
9
Association of Universities and High Education Institutions (ComUE), Paris-Est Créteil Val-de-Marne University, National Veterinary School, UMR (joint research unit) 1161 Virology, 94700 Maisons-Alfort, France. antonin.demange@vet-alfort.fr.
10
French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Animal Health Laboratory, UMR (joint research unit) 1161 Virology, 94701 Maisons-Alfort, France. nicole.pavio@anses.fr.
11
French National Institute for Agricultural Research (INRA), UMR (joint research unit) 1161 Virology, 94700 Maisons-Alfort, France. nicole.pavio@anses.fr.
12
Association of Universities and High Education Institutions (ComUE), Paris-Est Créteil Val-de-Marne University, National Veterinary School, UMR (joint research unit) 1161 Virology, 94700 Maisons-Alfort, France. nicole.pavio@anses.fr.

Abstract

During the past ten years, several new hepatitis E viruses (HEVs) have been identified in various animal species. In parallel, the number of reports of autochthonous hepatitis E in Western countries has increased as well, raising the question of what role these possible animal reservoirs play in human infections. The aim of this review is to present the recent discoveries of animal HEVs and their classification within the Hepeviridae family, their zoonotic and species barrier crossing potential, and possible use as models to study hepatitis E pathogenesis. Lastly, this review describes the transmission pathways identified from animal sources.

KEYWORDS:

animals; foodborne transmission; hepatitis E virus (HEV); zoonotic reservoir

PMID:
27706110
PMCID:
PMC5086606
DOI:
10.3390/v8100270
[Indexed for MEDLINE]
Free PMC Article

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