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Int J Mol Sci. 2016 Sep 30;17(10). pii: E1660.

Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice.

Author information

1
College of Pharmacy, Sahmyook University, Seoul 01795, Korea. jlyj777@gmail.com.
2
College of Pharmacy, Chungbuk National University, Cheongju 28644, Korea. littlei@daum.net.
3
College of Pharmacy, Sahmyook University, Seoul 01795, Korea. shelly7285@naver.com.
4
College of Pharmacy, Sahmyook University, Seoul 01795, Korea. leesw@live.co.kr.
5
College of Pharmacy, Sahmyook University, Seoul 01795, Korea. bhonest@naver.com.
6
College of Pharmacy, Sahmyook University, Seoul 01795, Korea. hite486@gmail.com.
7
College of Pharmacy, Sahmyook University, Seoul 01795, Korea. hskong0813@gmail.com.
8
College of Pharmacy, Sahmyook University, Seoul 01795, Korea. alexsongsu@syu.ac.kr.
9
Wellness R&D Center, Univera, Inc., Seoul 04782, Korea. ejayshin@univera.com.
10
Wellness R&D Center, Univera, Inc., Seoul 04782, Korea. sgildo@univera.com.
11
College of Pharmacy, Chungbuk National University, Cheongju 28644, Korea. cklee@chungbuk.ac.kr.
12
College of Pharmacy, Sahmyook University, Seoul 01795, Korea. kimkj@syu.ac.kr.

Abstract

Chronic stress generally experienced in our daily lives; is known to augment disease vulnerability by suppressing the host immune system. In the present study; the effect of modified Aloe polysaccharide (MAP) on chronic stress-induced immunosuppression was studied; this Aloe compound was characterized in our earlier study. Mice were orally administered with MAP for 24 days and exposed to electric foot shock (EFS; duration; 3 min; interval; 10 s; intensity; 2 mA) for 17 days. The stress-related immunosuppression and restorative effect of MAP were then analyzed by measuring various immunological parameters. MAP treatment alleviated lymphoid atrophy and body weight loss. The numbers of lymphocyte subsets were significantly normalized in MAP-treated mice. Oral administration of MAP also restored the proliferative activities of lymphocytes; ovalbumin (OVA)-specific T cell proliferation; antibody production; and the cell killing activity of cytotoxic T lymphocytes. In summary; oral administration of MAP ameliorated chronic EFS stress-induced immunosuppression.

KEYWORDS:

chronic stress; electric foot shock (EFS); immune restoration; in vivo cytotoxic T lymphocyte (CTL); modified Aloe polysaccharide (MAP)

PMID:
27706024
PMCID:
PMC5085693
DOI:
10.3390/ijms17101660
[Indexed for MEDLINE]
Free PMC Article

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