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Structure. 2016 Oct 4;24(10):1625-1627. doi: 10.1016/j.str.2016.09.003.

AXIN Shapes Tankyrase ARChitecture.

Author information

1
Divisions of Structural Biology and Cancer Biology, The Institute of Cancer Research (ICR), London SW7 3RP, UK. Electronic address: sebastian.guettler@icr.ac.uk.

Abstract

The poly(ADP-ribose)polymerase (PARP) Tankyrase uses ankyrin repeat modules to capture substrates via Tankyrase-binding peptide motifs. In this issue of Structure, Eisemann et al. (2016) describe how the signaling protein AXIN can access and conformationally adapt the multivalent ankyrin repeat region of Tankyrase and discuss potential implications for enzymatic substrate modification.

PMID:
27705813
DOI:
10.1016/j.str.2016.09.003
[Indexed for MEDLINE]
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