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Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11943-11948. Epub 2016 Oct 4.

Predictability and hierarchy in Drosophila behavior.

Author information

1
Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544 gordon.berman@emory.edu.
2
Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.

Abstract

Even the simplest of animals exhibit behavioral sequences with complex temporal dynamics. Prominent among the proposed organizing principles for these dynamics has been the idea of a hierarchy, wherein the movements an animal makes can be understood as a set of nested subclusters. Although this type of organization holds potential advantages in terms of motion control and neural circuitry, measurements demonstrating this for an animal's entire behavioral repertoire have been limited in scope and temporal complexity. Here, we use a recently developed unsupervised technique to discover and track the occurrence of all stereotyped behaviors performed by fruit flies moving in a shallow arena. Calculating the optimally predictive representation of the fly's future behaviors, we show that fly behavior exhibits multiple time scales and is organized into a hierarchical structure that is indicative of its underlying behavioral programs and its changing internal states.

KEYWORDS:

Drosophila; behavior; hierarchy; information bottleneck

PMID:
27702892
PMCID:
PMC5081631
DOI:
10.1073/pnas.1607601113
[Indexed for MEDLINE]
Free PMC Article

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