Format

Send to

Choose Destination
Mech Dev. 2017 Apr;144(Pt B):150-155. doi: 10.1016/j.mod.2016.09.004. Epub 2016 Oct 1.

Development and diabetes on the fly.

Author information

1
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM Juriquilla, Boulevard Juriquilla #3001, Querétaro 76230, Mexico.
2
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM Juriquilla, Boulevard Juriquilla #3001, Querétaro 76230, Mexico. Electronic address: juanriesgo@prodigy.net.mx.

Abstract

We review the use of a model organism to study the effects of a slow course, degenerative disease: namely, diabetes mellitus. Development and aging are biological phenomena entailing reproduction, growth, and differentiation, and then decline and progressive loss of functionality leading ultimately to failure and death. It occurs at all biological levels of organization, from molecular interactions to organismal well being and homeostasis. Yet very few models capable of addressing the different levels of complexity in these chronic, developmental phenomena are available to study, and model organisms are an exception and a welcome opportunity for these approaches. Genetic model organisms, like the common fruit fly, Drosophila melanogaster, offer the possibility of studying the panoply of life processes in normal and diseased states like diabetes mellitus, from a plethora of different perspectives. These long-term aspects are now beginning to be characterized.

KEYWORDS:

Development; Diabetes; Drosophila melanogaster; Lifespan; Model organism

PMID:
27702607
DOI:
10.1016/j.mod.2016.09.004
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center