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Mech Ageing Dev. 2017 Jul;165(Pt A):17-26. doi: 10.1016/j.mad.2016.09.008. Epub 2016 Oct 1.

DNA damage-induced inflammation and nuclear architecture.

Author information

1
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece.
2
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece; Department of Biology, University of Crete, Vassilika Vouton, GR71409, Heraklion, Crete, Greece. Electronic address: garinis@imbb.forth.gr.

Abstract

Nuclear architecture and the chromatin state affect most-if not all- DNA-dependent transactions, including the ability of cells to sense DNA lesions and restore damaged DNA back to its native form. Recent evidence points to functional links between DNA damage sensors, DNA repair mechanisms and the innate immune responses. The latter raises the question of how such seemingly disparate processes operate within the intrinsically complex nuclear landscape and the chromatin environment. Here, we discuss how DNA damage-induced immune responses operate within chromatin and the distinct sub-nuclear compartments highlighting their relevance to chronic inflammation.

KEYWORDS:

DNA damage; Inflammation; Innate immunity; Nuclear architecture

PMID:
27702596
DOI:
10.1016/j.mad.2016.09.008
[Indexed for MEDLINE]

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