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Int J Hematol. 2017 Jan;105(1):104-108. doi: 10.1007/s12185-016-2104-1. Epub 2016 Oct 3.

Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?

Author information

1
Myeloma Unit, Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43126, Parma, Italy.
2
"Ematologia e CTMO", "Azienda Ospedaliero-Universitaria di Parma", Parma, Italy.
3
Pathology Unit, "Azienda Ospedaliero-Universitaria di Parma", Parma, Italy.
4
Laboratory of Pre-clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
5
Haematopathology Diagnostic Area- Pathology Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
6
Department of Oncology and Hemato-Oncology, University of Milano, Milan, Italy.
7
Hematology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
8
Myeloma Unit, Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43126, Parma, Italy. nicola.giuliani@unipr.it.
9
"Ematologia e CTMO", "Azienda Ospedaliero-Universitaria di Parma", Parma, Italy. nicola.giuliani@unipr.it.

Abstract

The skin is a possible site of extramedullary localization in multiple myeloma (MM) patients; however, the mechanisms involved in this process are poorly understood. We describe the case of a refractory MM patient who developed a cutaneous localization under bortezomib treatment and we further expanded observations in other eight MM patients. We focused on the expression of genes involved in plasma cell skin homing, including CCR10, which was highly expressed. Moreover, we observed a lack of CXCR4 surface expression and the down-regulation of ICAM1/CD54 throughout the progression of the disease, suggesting a possible mechanism driving the escape of MM cells from the bone marrow into the skin.

KEYWORDS:

Bone marrow; Extramedullary disease; Multiple myeloma; Skin homing

PMID:
27699576
DOI:
10.1007/s12185-016-2104-1
[Indexed for MEDLINE]

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