Format

Send to

Choose Destination
Inflamm Res. 2017 Jan;66(1):13-15. doi: 10.1007/s00011-016-0994-2. Epub 2016 Oct 3.

M2 macrophages do not fly into a "RAGE".

Author information

1
Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca, Chile. arojasr@ucm.cl.
2
Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca, Chile.

Abstract

Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, where the classically activated type 1 macrophages (M1) and the alternative activated type 2 macrophages (M2) represent two extreme phenotypes. In this commentary, based on very recent research findings, we intend to highlight how complex could be the crosstalk among all components of tumor stroma, where the coexistence of non-natural partners may even skew the canonical responses that we can expect.

KEYWORDS:

HMGB1; M2 macrophages; Macrophage polarization; Receptor of advanced glycation end products; Tumor microenvironment

PMID:
27699448
DOI:
10.1007/s00011-016-0994-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center