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Eur J Obstet Gynecol Reprod Biol. 2016 Nov;206:172-176. doi: 10.1016/j.ejogrb.2016.09.001. Epub 2016 Sep 23.

The effects of uterine artery embolization on ovarian reserve.

Author information

1
Department of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea.
2
Department of Anesthesiology and Pain Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea.
3
Department of Radiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea.
4
Department of Radiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea. Electronic address: yawoo114@naver.com.

Abstract

OBJECTIVE:

To evaluate the effects of UAE for symptomatic uterine fibroids on ovarian reserve based on AMH.

STUDY DESIGN:

This was a retrospective study conducted between March 2011 and October 2014. All women underwent UAE. At baseline and at the 3-month and 12-month follow-up visits, serum anti-Müllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels were assessed, and ovarian volume and antral follicle count (AFC) were evaluated in each patient.

RESULTS:

There were no statistically significant differences in serum E2, LH, or FSH levels or in ovarian volume 3 or 12 months after UAE (P=0.8194, P=0.3976, P=0.4766, and P=0.6822, respectively). However, AMH and AFC were significantly different 3 and 12 months after the procedure (P=0.00, P=0.029 and P=0.00, P=0.00, respectively). AMH levels remained low after 12 months of follow-up compared to the expected AMH levels. A statistically significant recovery of serum AMH at 12 months compared to at 3 months in those <40 years of age (P=0.00), but not in those ≥40 years (P=0.837).

CONCLUSIONS:

Ovarian reserve appears to be affected by UAE in premenopausal women. However, younger ovaries (according to biological ovarian age) exhibit a greater capacity for recovery after ovarian damage. Therefore, larger studies are needed for more conclusive results.

KEYWORDS:

Anti-Müllerian hormone; Ovarian reserve; Uterine artery embolization

PMID:
27697621
DOI:
10.1016/j.ejogrb.2016.09.001
[Indexed for MEDLINE]

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