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Alzheimers Dement. 2017 Mar;13(3):205-216. doi: 10.1016/j.jalz.2016.08.005. Epub 2016 Sep 30.

Defining imaging biomarker cut points for brain aging and Alzheimer's disease.

Author information

1
Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: jack.clifford@mayo.edu.
2
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
3
Department of Nuclear Medicine, Mayo Clinic, Rochester, MN, USA.
4
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
5
Department of Information Technology, Mayo Clinic, Rochester, MN, USA.
6
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
7
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Abstract

INTRODUCTION:

Our goal was to develop cut points for amyloid positron emission tomography (PET), tau PET, flouro-deoxyglucose (FDG) PET, and MRI cortical thickness.

METHODS:

We examined five methods for determining cut points.

RESULTS:

The reliable worsening method produced a cut point only for amyloid PET. The specificity, sensitivity, and accuracy of cognitively impaired versus young clinically normal (CN) methods labeled the most people abnormal and all gave similar cut points for tau PET, FDG PET, and cortical thickness. Cut points defined using the accuracy of cognitively impaired versus age-matched CN method labeled fewer people abnormal.

DISCUSSION:

In the future, we will use a single cut point for amyloid PET (standardized uptake value ratio, 1.42; centiloid, 19) based on the reliable worsening cut point method. We will base lenient cut points for tau PET, FDG PET, and cortical thickness on the accuracy of cognitively impaired versus young CN method and base conservative cut points on the accuracy of cognitively impaired versus age-matched CN method.

KEYWORDS:

Alzheimer's MRI; Alzheimer's biomarkers; Alzheimer's disease; Alzheimer's imaging; Amyloid PET; FDG PET; Quantitative imaging; Tau PET

PMID:
27697430
PMCID:
PMC5344738
DOI:
10.1016/j.jalz.2016.08.005
[Indexed for MEDLINE]
Free PMC Article

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