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J Cataract Refract Surg. 2016 Sep;42(9):1302-1311. doi: 10.1016/j.jcrs.2016.06.035.

Outcomes of topography-guided versus wavefront-optimized laser in situ keratomileusis for myopia in virgin eyes.

Author information

1
From the Advanced Eye Centre (Jain, Malhotra, Parasi, Kumar), Post Graduate Institute of Medical Education and Research, Chandigarh, India; the Department of Ophthalmology (Moshirfar), Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA. Electronic address: aronkjain@yahoo.com.
2
From the Advanced Eye Centre (Jain, Malhotra, Parasi, Kumar), Post Graduate Institute of Medical Education and Research, Chandigarh, India; the Department of Ophthalmology (Moshirfar), Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA.

Abstract

PURPOSE:

To compare the outcomes of topography-guided and wavefront-optimized treatment in patients having laser in situ keratomileusis (LASIK) for myopia.

SETTING:

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

DESIGN:

Prospective contralateral-eye case study.

METHODS:

Patients had topography-guided LASIK in 1 eye and wavefront-optimized LASIK in the contralateral eye using the Customized Refractive Surgery Master software and Mel 80 excimer laser. Refractive (residual manifest refraction spherical equivalent [MRSE], higher-order aberrations [HOAs]), and visual (uncorrected distance visual acuity [UDVA] and photopic and mesopic contrast sensitivity) outcomes were prospectively analyzed 6 months postoperatively.

RESULTS:

The study comprised 35 patients. The UDVA was 0.0 logMAR or better and the postoperative residual MRSE was ±0.50 diopter in 94.29% of eyes in the topography-guided group and 85.71% of eyes in the wavefront-optimized group (P = .09). More eyes in the topography-guided group than in the wavefront-optimized group had a UDVA of -0.1 logMAR or better (P = .04). Topography-guided LASIK was associated with less deterioration of mesopic contrast sensitivity at higher spatial frequencies (12 cycles per degree [cpd] and 18 cpd) and lower amounts of induced coma (P = .04) and spherical aberration (P = .04). Less stromal tissue was ablated in the topography-guided group (mean 61.57 μm ± 16.23 [SD]) than in the wavefront-optimized group (mean 79.71 ± 14.81 μm) (P < .001).

CONCLUSION:

Although topography-guided LASIK and wavefront-optimized LASIK gave excellent results, topography-guided LASIK was associated with better contrast sensitivity, lower induction of HOAs, and a smaller amount of tissue ablation.

FINANCIAL DISCLOSURE:

None of the authors has a financial or proprietary interest in any material or method mentioned.

PMID:
27697248
DOI:
10.1016/j.jcrs.2016.06.035
[Indexed for MEDLINE]

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