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Inflammation. 2017 Feb;40(1):303-310. doi: 10.1007/s10753-016-0453-9.

Interleukin-35: a Potential Therapeutic Agent for Autoimmune Diseases.

Guan SY1,2, Leng RX1,2, Khan MI1,2, Qureshi H1,2, Li XP3, Ye DQ1,2, Pan HF4,5.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China.
2
Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
3
Department of Rheumatology and Immunology, Anhui Provincial Hospital, 17 Lujiang Road, Hefei, Anhui, China.
4
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China. panhaifeng1982@sina.com.
5
Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China. panhaifeng1982@sina.com.

Abstract

Autoimmune diseases contain a large number of pathologies characterized by various factors that contribute to a breakdown in self-tolerance. Cytokine-mediated immunity plays an essential role in the pathogenesis of varieties of autoimmune diseases. Recent studies reveal that interleukin-35 (IL-35), a newly identified cytokine of IL-12 family, is implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), etc. In this review, we will discuss the biological features of IL-35 and summarize recent advances in the role of IL-35 in the development and pathogenesis of autoimmune diseases; the discoveries gained from these findings might translate into future therapies for these diseases.

KEYWORDS:

Th17 cells; Treg cells; autoimmune diseases; interleukin-35; therapeutic agent

PMID:
27696334
DOI:
10.1007/s10753-016-0453-9
[Indexed for MEDLINE]

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