Format

Send to

Choose Destination
Sci Rep. 2016 Oct 3;6:34722. doi: 10.1038/srep34722.

Coronary artery calcium is associated with cortical thinning in cognitively normal individuals.

Lee JS1,2, Kang D3,4, Jang YK1,2, Kim HJ1,2, Na DL1,2,4, Shin HY5, Kang M5, Yang JJ6, Lee JM6, Lee J7, Kim YJ8, Park KC9, Guallar E3,10,11,12, Seo SW1,2,4,13, Cho J3,4,10,13.

Author information

1
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
2
Neuroscience Center, Samsung Medical Center 06351, Seoul, Korea.
3
Center for Clinical Epidemiology, Samsung Medical Center 06351, Seoul, Korea.
4
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Korea.
5
Health Promotion Center, Samsung Medical Center 06351, Seoul, Korea.
6
Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
7
Department of Neurology, Chungnam National University Hospital, Daejeon, Korea.
8
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
9
Department of Neurology, Kyung Hee University School of Medicine, Seoul, Korea.
10
Department of Epidemiology, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, USA.
11
Department of Medicine, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, USA.
12
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, USA.
13
Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul 06351, Korea.

Abstract

To evaluate the association between coronary artery calcium (CAC) and cortical thickness in a large sample of cognitively normal individuals, with special emphasis in determining if the association thickness has regional brain specificity and if it is mediated by white matter hyperintensities (WMH). A total of 512 participants were included in this study. CAC scores were assessed by multi-detector computed tomography. Cortical thickness was measured using a surface-based method. Linear mixed models were used to assess the association between CAC scores and cortical thickness. In fully adjusted models, increased CAC scores were associated with cortical thinning across several brain regions, which generally overlapped with the distribution of default mode network. The association between CAC scores and cortical thickness was significantly stronger in participants with moderate or severe WMH compared to those with none or mild WMH, even though CAC scores were not associated with WMH. In cognitively normal adults, CAC was associated with cortical thinning in areas related to cognitive function. This association was evident after adjusting for multiple coronary artery disease risk factors and for WMH, suggesting that CAC may be more closely related to Alzheimer's Disease-type disease rather than to cerebral small vessel disease.

PMID:
27694965
PMCID:
PMC5046153
DOI:
10.1038/srep34722
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center