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Biochem Biophys Res Commun. 2016 Oct 28;479(4):747-752. doi: 10.1016/j.bbrc.2016.09.140. Epub 2016 Sep 28.

Dietary gamma oryzanol plays a significant role in the anti-inflammatory activity of rice bran oil by decreasing pro-inflammatory mediators secreted by peritoneal macrophages of rats.

Author information

1
Department of Lipid Science, CSIR-Central Food Technological Research Institute, Mysuru, 570020 Karnataka, India.
2
Department of Diabetes, Endocrinology and Metabolism, University of Illinois at Chicago, 60607, USA.
3
Department of Lipid Science, CSIR-Central Food Technological Research Institute, Mysuru, 570020 Karnataka, India. Electronic address: lokesh_lipids@yahoo.co.in.

Abstract

Ricebran oil (RBO) is promoted as heart friendly oil because of its ability to maintain serum lipids at desirable levels. Inflammation also plays an important role on cardiovascular health. The role of minor constituents present in unsaponifiable fraction (UF) of RBO on inflammatory markers is not well understood. To evaluate this, we have taken RBO with UF (RBO-N), RBO stripped of UF (RBO-MCR) and RBO-MCR supplemented with UF from RBO (UFRBO) or Gamma-Oryzanol (γ-ORY) were added in AIN-93 diets which was then fed to Wistar rats for a period of 60 days. Groundnut oil with UF (GNO-N), UF removed GNO (GNO-MCR) and GNO-MCR supplemented with UF from RBO or γ-ORY was also used for comparison. The peritoneal macrophages from the rats were activated and pro-inflammatory mediators such as Reactive Oxygen Species (ROS), eicosanoids, cytokines, hydrolytic enzymes of lysosomal origin were monitored. The results indicated that UF of RBO and γ-ORY supplemented in the dietary oils play a significant role in reducing the secretion of pro-inflammatory mediators by macrophages. Hence γ-ORY in RBO significantly contributed to the anti-inflammatory properties of RBO.

KEYWORDS:

Anti-inflammatory activity; Macrophages; Pro-inflammatory mediators; Rice bran oil; Unsaponifiable fraction; γ-Oryzanol

PMID:
27693794
DOI:
10.1016/j.bbrc.2016.09.140
[Indexed for MEDLINE]

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