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Stem Cell Reports. 2016 Oct 11;7(4):583-590. doi: 10.1016/j.stemcr.2016.09.001. Epub 2016 Sep 29.

Restoration of Corneal Transparency by Mesenchymal Stem Cells.

Author information

1
Schepens Eye Research Institute, Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA 02114, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
2
Schepens Eye Research Institute, Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA 02114, USA; Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.
3
Schepens Eye Research Institute, Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA 02114, USA.
4
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02114, USA.
5
Schepens Eye Research Institute, Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA 02114, USA; L.V. Prasad Eye Institute, Bhubaneswar, Odisha 751024, India.
6
Schepens Eye Research Institute, Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA 02114, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Electronic address: sunil_chauhan@meei.harvard.edu.

Abstract

Transparency of the cornea is indispensable for optimal vision. Ocular trauma is a leading cause of corneal opacity, leading to 25 million cases of blindness annually. Recently, mesenchymal stem cells (MSCs) have gained prominence due to their inflammation-suppressing and tissue repair functions. Here, we investigate the potential of MSCs to restore corneal transparency following ocular injury. Using an in vivo mouse model of ocular injury, we report that MSCs have the capacity to restore corneal transparency by secreting high levels of hepatocyte growth factor (HGF). Interestingly, our data also show that HGF alone can restore corneal transparency, an observation that has translational implications for the development of HGF-based therapy.

PMID:
27693426
PMCID:
PMC5063582
DOI:
10.1016/j.stemcr.2016.09.001
[Indexed for MEDLINE]
Free PMC Article

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