Format

Send to

Choose Destination
Cell Metab. 2017 Jan 10;25(1):11-26. doi: 10.1016/j.cmet.2016.08.016. Epub 2016 Sep 29.

Tissue Immunometabolism: Development, Physiology, and Pathobiology.

Author information

1
Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0795, USA.
2
Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0795, USA; Departments of Physiology and Medicine, University of California, San Francisco, CA 94143-0795, USA. Electronic address: ajay.chawla@ucsf.edu.

Abstract

Evolution of metazoans resulted in the specialization of cellular and tissue function. This was accomplished by division of labor, which allowed tissue parenchymal cells to prioritize their core functions while ancillary functions were delegated to tissue accessory cells, such as immune, stromal, and endothelial cells. In metabolic organs, the accessory cells communicate with their clients, the tissue parenchymal cells, to optimize cellular processes, allowing organisms to adapt to changes in their environment. Here, we discuss tissue immunometabolism from this vantage point and use examples from adipose tissues (white, beige, and brown) and liver to outline the general principles by which accessory cells support metabolic homeostasis in parenchymal cells. A corollary of this model is that disruption of communication between client and accessory cells might predispose metabolic organs to the development of disease.

PMID:
27693378
PMCID:
PMC5226870
DOI:
10.1016/j.cmet.2016.08.016
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center