Format

Send to

Choose Destination
Alzheimers Dement. 2017 May;13(5):531-540. doi: 10.1016/j.jalz.2016.08.013. Epub 2016 Sep 28.

Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease.

Author information

1
Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: a.leeuwis@vumc.nl.
2
Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
3
Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands.
4
Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
5
Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands.
6
Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands.
7
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands; Institutes of Neurology and Healthcare Engineering, UCL, London, United Kingdom.
8
Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.

Abstract

INTRODUCTION:

We examined the association between decreased cerebral blood flow (CBF) and cognitive impairment in Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD).

METHODS:

We included 161 AD, 95 MCI, and 143 SCD patients from the Amsterdam Dementia Cohort. We used 3-T pseudo-continuous arterial spin labeling to estimate whole-brain and regional partial volume-corrected CBF. Neuropsychological tests covered global cognition and five cognitive domains. Associations were investigated using linear regression analyses.

RESULTS:

In the whole sample, reduced overall and regional CBF was associated with impairment in all cognitive domains. We found significant interactions between diagnosis and CBF for language and between diagnosis and parietal CBF for global cognition and executive functioning. Stratification showed that decreased CBF was associated with worse performance in AD patients but not in MCI or SCD.

DISCUSSION:

Our results suggest that CBF may have potential as a functional marker of disease severity.

KEYWORDS:

Alzheimer's disease; Arterial spin labeling; Brain perfusion; Cognition; Dementia

PMID:
27693109
DOI:
10.1016/j.jalz.2016.08.013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center