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Trends Mol Med. 2016 Nov;22(11):946-957. doi: 10.1016/j.molmed.2016.09.003. Epub 2016 Sep 28.

Urinary Tract Infection: Pathogenesis and Outlook.

Author information

1
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
2
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: dhunstad@wustl.edu.

Abstract

The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial UTI. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental biological investigation. In this review, we highlight contemporary advances in the field of UTI pathogenesis and how these might inform both our clinical perspective and future scientific priorities.

KEYWORDS:

Escherichia coli; cystitis; pyelonephritis; urinary tract infection

PMID:
27692880
PMCID:
PMC5159206
DOI:
10.1016/j.molmed.2016.09.003
[Indexed for MEDLINE]
Free PMC Article

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