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Int Rev Cell Mol Biol. 2016;327:1-42. doi: 10.1016/bs.ircmb.2016.05.003. Epub 2016 Jun 24.

Sensing the Environment Through Sestrins: Implications for Cellular Metabolism.

Author information

1
Department of Human and Molecular Genetics, Goodwin Research Laboratories, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, United States.
2
Department of Human and Molecular Genetics, Goodwin Research Laboratories, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, United States. Electronic address: Andrei.Budanov@vcuhealth.org.

Abstract

Sestrins are a family of stress-responsive genes that have evolved to attenuate damage induced by stress caused to the cell. By virtue of their antioxidant activity, protein products of Sestrin genes prevent the accumulation of reactive oxygen species within the cell, thereby attenuating the detrimental effects of oxidative stress. In parallel, Sestrins participate in several signaling pathways that control the activity of the target of rapamycin protein kinase (TOR). TOR is a crucial sensor of intracellular and extracellular conditions that promotes cell growth and anabolism when nutrients and growth factors are abundant. In addition to reacting to stress-inducing insults, Sestrins also monitor the changes in the availability of nutrients, which allows them to serve as a key checkpoint for the TOR-regulated signaling pathways. In this review, we will discuss how Sestrins integrate signals from numerous stress- and nutrient-responsive signaling pathways to orchestrate cellular metabolism and support cell viability.

KEYWORDS:

AMPK; GATOR; Sestrin; mTOR; metabolism

PMID:
27692174
DOI:
10.1016/bs.ircmb.2016.05.003
[Indexed for MEDLINE]

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