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Elife. 2016 Oct 3;5. pii: e20252. doi: 10.7554/eLife.20252.

Sparse activity of identified dentate granule cells during spatial exploration.

Author information

1
Werner-Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
2
Graduate Training Centre of Neuroscience - IMPRS, University of Tübingen, Tübingen, Germany.
3
Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
4
Bernstein Centre for Computational Neuroscience, University of Tübingen, Tübingen, Germany.

Abstract

In the dentate gyrus - a key component of spatial memory circuits - granule cells (GCs) are known to be morphologically diverse and to display heterogeneous activity profiles during behavior. To resolve structure-function relationships, we juxtacellularly recorded and labeled single GCs in freely moving rats. We found that the vast majority of neurons were silent during exploration. Most active GCs displayed a characteristic spike waveform, fired at low rates and showed spatial activity. Primary dendritic parameters were sufficient for classifying neurons as active or silent with high accuracy. Our data thus support a sparse coding scheme in the dentate gyrus and provide a possible link between structural and functional heterogeneity among the GC population.

KEYWORDS:

dentate gyrus; granule cell; juxtacellular; neuroscience; place cell; rat; spatial navigation

PMID:
27692065
PMCID:
PMC5077296
DOI:
10.7554/eLife.20252
[Indexed for MEDLINE]
Free PMC Article

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