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Public Health Nutr. 2017 Feb;20(3):549-555. doi: 10.1017/S1368980016002597. Epub 2016 Oct 3.

Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes: a 2-year randomized controlled trial.

Author information

1
1Department of Public Health, Faculty of Health Sciences,Ben-Gurion University of the Negev,PO Box 653,Beer-Sheva 84105,Israel.
2
2Soroka University Medical Center,Beer-Sheva,Israel.
3
3Nuclear Research Center Negev,Dimona,Israel.
4
4Department of Medicine,University of Leipzig,Leipzig,Germany.
5
5Channing Division of Network Medicine,Department of Medicine,Brigham and Women's Hospital and Harvard School of Public Health,Boston,MA,USA.

Abstract

OBJECTIVE:

To generate evidence-based conclusions about the effect of wine consumption on weight gain and abdominal fat accumulation and distribution in patients with type 2 diabetes.

DESIGN:

In the 2-year randomized controlled CASCADE (CArdiovaSCulAr Diabetes & Ethanol) trial, patients following a Mediterranean diet were randomly assigned to drink 150 ml of mineral water, white wine or red wine with dinner for 2 years. Visceral adiposity and abdominal fat distribution were measured in a subgroup of sixty-five participants, using abdominal MRI.

SETTING:

Ben-Gurion University of the Negev, Soroka-Medical Center and the Nuclear Research Center Negev, Israel.

SUBJECTS:

Alcohol-abstaining adults with well-controlled type 2 diabetes.

RESULTS:

Forty-eight participants (red wine, n 27; mineral water, n 21) who completed a second MRI measurement were included in the 2-year analysis. Similar weight losses (sd) were observed: red wine 1·3 (3·9) kg; water 1·0 (4·2) kg (P=0·8 between groups). Changes (95 % CI) in abdominal adipose-tissue distribution were similar: red wine, visceral adipose tissue (VAT) -3·0 (-8·0, 2·0) %, deep subcutaneous adipose tissue (DSAT) +5·2 (-1·1, 11·6) %, superficial subcutaneous adipose tissue (SSAT) -1·9 (-5·0, 1·2) %; water, VAT -3·2 (-8·9, 2·5) %, DSAT +2·9 (-2·8, 8·6) %, SSAT -0·15 (-3·3, 2·9) %. No changes in antidiabetic medication and no substantial changes in energy intake (+126 (sd 2889) kJ/d (+30·2 (sd 690) kcal/d), P=0·8) were recorded. A 2-year decrease in glycated Hb (β=0·28, P=0·05) was associated with a decrease in VAT.

CONCLUSIONS:

Moderate wine consumption, as part of a Mediterranean diet, in persons with controlled diabetes did not promote weight gain or abdominal adiposity.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00784433.

KEYWORDS:

Abdominal adipose tissue; MRI; Mediterranean diet; Type 2 diabetes; Wine

PMID:
27692023
DOI:
10.1017/S1368980016002597
[Indexed for MEDLINE]

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