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Nutrients. 2016 Sep 27;8(10). pii: E544.

A Trypsin Inhibitor from Tamarind Reduces Food Intake and Improves Inflammatory Status in Rats with Metabolic Syndrome Regardless of Weight Loss.

Author information

1
Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. fabicoimbra@hotmail.com.
2
Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. vanessalima_nutri@yahoo.com.br.
3
Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. izaelsousa@hotmail.com.
4
Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. amanda-nut@hotmail.com.
5
Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. alexandreserquiz@gmail.com.
6
Course of Nutrition, Potiguar University, Natal RN 59056-000, Brazil. alexandreserquiz@gmail.com.
7
Course of Veterinary Medicine, Potiguar University, Natal RN 59056-000, Brazil. mairalima4@hotmail.com.
8
Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. raphaserquiz@hotmail.com.
9
Technical School Health, Potiguar University, Natal RN 59056-000, Brazil. raphaserquiz@hotmail.com.
10
Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. brunalimamaciel@gmail.com.
11
Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. brunalimamaciel@gmail.com.
12
Tropical Medicine Institute (TMI), Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. brunalimamaciel@gmail.com.
13
Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. afuchoa2003@yahoo.com.br.
14
Tropical Medicine Institute (TMI), Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. afuchoa2003@yahoo.com.br.
15
Department of Cell Biology and Genetics, Center for Biosciences, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. afuchoa2003@yahoo.com.br.
16
Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. elizeu.ufrn@gmail.com.
17
Tropical Medicine Institute (TMI), Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. elizeu.ufrn@gmail.com.
18
Department of Biochemistry, Center for Biosciences, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. elizeu.ufrn@gmail.com.
19
Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. aharaujomorais@gmail.com.
20
Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal RN 59078-970, Brazil. aharaujomorais@gmail.com.

Abstract

Trypsin inhibitors are studied in a variety of models for their anti-obesity and anti-inflammatory bioactive properties. Our group has previously demonstrated the satietogenic effect of tamarind seed trypsin inhibitors (TTI) in eutrophic mouse models and anti-inflammatory effects of other trypsin inhibitors. In this study, we evaluated TTI effect upon satiety, biochemical and inflammatory parameters in an experimental model of metabolic syndrome (MetS). Three groups of n = 5 male Wistar rats with obesity-based MetS received for 10 days one of the following: (1) Cafeteria diet; (2) Cafeteria diet + TTI (25 mg/kg); and (3) Standard diet. TTI reduced food intake in animals with MetS. Nevertheless, weight gain was not different between studied groups. Dyslipidemia parameters were not different with the use of TTI, only the group receiving standard diet showed lower very low density lipoprotein (VLDL) and triglycerides (TG) (Kruskal-Wallis, p < 0.05). Interleukin-6 (IL-6) production did not differ between groups. Interestingly, tumor necrosis factor-alpha (TNF-α) was lower in animals receiving TTI. Our results corroborate the satietogenic effect of TTI in a MetS model. Furthermore, we showed that TTI added to a cafeteria diet may decrease inflammation regardless of weight loss. This puts TTI as a candidate for studies to test its effectiveness as an adjuvant in MetS treatment.

KEYWORDS:

Glycemia; TNF-α; cafeteria diet; obesity

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