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Adv Mater. 2016 Dec;28(46):10195-10203. doi: 10.1002/adma.201602763. Epub 2016 Sep 30.

Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle-functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy.

Author information

1
Beijing Key Laboratory of Function Materials for Molecule and Structure Construction, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
2
Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
3
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
4
School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China.
5
Cape Breton University, 1250 Grand Lake Road, Sydney, NS, B1P 6L2, Canada.
6
Laboratory of Industrial Physics, Department of Physics, University of Turku, FI-20014, Turku, Finland.

Abstract

Gold nanorods, DNA origami, and porous silicon nanoparticle-functionalized biocompatible double emulsion are developed for versatile molecular targeted therapeutics and antibody combination therapy. This advanced photothermal responsive all-in-one biocompatible platform can be easily formed with great therapeutics loading capacity for different cancer treatments with synergism and multidrug resistance inhibition, which has great potential in advancing biomedical applications.

KEYWORDS:

DNA origami; biomedical applications; drug delivery; multidrug resistance inhibition; silicon nanoparticles

PMID:
27689681
DOI:
10.1002/adma.201602763
[Indexed for MEDLINE]

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