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Leuk Lymphoma. 2017 Apr;58(4):842-850. doi: 10.1080/10428194.2016.1217525. Epub 2016 Aug 11.

T-cell subsets in lymph nodes identify a subgroup of follicular lymphoma patients with favorable outcome.

Author information

1
a Department of Hematology , Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain.
2
b Hematopathology Unit, Department of Pathology , Hospital Clínic, IDIBAPS , Barcelona , Spain.
3
c Pathology Department, University of Barcelona , Barcelona , Spain.
4
d Department of Pathology , School of Medicine, Tokai University , Isehara , Japan.

Abstract

We have analyzed in lymph nodes at diagnosis of 75 patients with follicular lymphoma (FL) the relationship between different T-cell subpopulations, assessed by immunohistochemistry (IHC) and flow cytometry (FC), with the outcome. CD4+ cells were the most abundant T-cells in tumor tissue sections, whilst CD57+ cells were the less frequent. In addition to nonambulatory performance status, advanced stage and FLIPI, low CD4+CD57+/CD4+ ratio (p = .041), and low CD4+/CD8+ ratio (p = .008) predicted poor overall survival (OS). Multivariate analysis showed that CD4+CD57+/CD4+ ratio was the most important variable for OS. In conclusion, T-cell subpopulations, including CD4+CD57+/CD4+ ratio analyzed by FC, could identify FL patients with favorable outcome.

KEYWORDS:

CD4+CD57+ cells; Follicular lymphoma; prognosis

PMID:
27687692
DOI:
10.1080/10428194.2016.1217525
[Indexed for MEDLINE]

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