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J Microbiol. 2016 Oct;54(10):639-45. doi: 10.1007/s12275-016-6362-7. Epub 2016 Sep 30.

Global transcriptional regulator TrmB family members in prokaryotes.

Author information

1
Department of Biology, Kyung Hee University, Seoul, 02447, Republic of Korea.
2
Department of Biology, Kyung Hee University, Seoul, 02447, Republic of Korea. sungjaelee@khu.ac.kr.
3
Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea. sungjaelee@khu.ac.kr.

Abstract

Members of the TrmB family act as global transcriptional regulators for the activation or repression of sugar ABC transporters and central sugar metabolic pathways, including glycolytic, gluconeogenic, and other metabolic pathways, and also as chromosomal stabilizers in archaea. As a relatively newly classified transcriptional regulator family, there is limited experimental evidence for their role in Thermococcales, halophilic archaeon Halobacterium salinarum NRC1, and crenarchaea Sulfolobus strains, despite being one of the extending protein families in archaea. Recently, the protein structures of Pyrococcus furiosus TrmB and TrmBL2 were solved, and the transcriptomic data uncovered by microarray and ChIP-Seq were published. In the present review, recent evidence of the functional roles of TrmB family members in archaea is explained and extended to bacteria.

KEYWORDS:

TrmB family members; extremophile; global transcriptional regulator; prokaryote; sugar-binding motif

PMID:
27687225
DOI:
10.1007/s12275-016-6362-7
[Indexed for MEDLINE]

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