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Lupus. 2017 Jun;26(7):773-776. doi: 10.1177/0961203316669242. Epub 2016 Sep 30.

Long-term systemic lupus erythematosus disease control after allogeneic bone marrow transplantation.

Author information

1
Johns Hopkins Hospital and Health System, Baltimore, MD, USA.

Abstract

Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has improved the availability and safety of alloBMT permitting its exploration in severe-refractory autoimmune illnesses. We report the six-year follow-up of a young female whose refractory SLE-associated nephrosis resolved after RIC alloBMT with PTCy.

KEYWORDS:

Systemic lupus erythematosus; alloBMT

PMID:
27687020
PMCID:
PMC5374037
DOI:
10.1177/0961203316669242
[Indexed for MEDLINE]
Free PMC Article

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