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J Matern Fetal Neonatal Med. 2017 Jun;30(11):1349-1354. doi: 10.1080/14767058.2016.1214123. Epub 2016 Aug 10.

Amniopatch treatment of iatrogenic preterm premature rupture of membranes (iPPROM) after fetoscopic laser surgery for twin-twin transfusion syndrome.

Author information

1
a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California , Los Angeles , CA , USA.
2
b Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, University of Missouri-Kansas City School of Medicine, Children's Mercy Hospital , Kansas City , MO , USA , and.
3
c Childbirth Research Associates , North Hollywood , CA , USA.

Abstract

OBJECTIVES:

Amniopatch is a proposed treatment of iatrogenic preterm premature rupture of membranes (iPPROM). We studied characteristics associated with successful amniopatch treatment of iPPROM after fetoscopic laser surgery for twin-twin transfusion syndrome.

METHODS:

Patients with iPPROM within 15 days of laser surgery treated with an amniopatch were studied. Factors associated with amniopatch success (i.e. cessation of leakage with normalization of amniotic fluid volume) were tested univariately and in multivariate logistic regression models. Continuous variables are expressed as median (range).

RESULTS:

Of 1124 patients undergoing laser surgery, 19 (1.7%) had iPPROM and subsequent amniopatch. Twelve (63.2%) were successful. Latency in days from iPPROM to delivery was greater in the successful group (114.0 [87.0-141.0]) versus (44.0 [3.9-88.0], p = 0.0005), which translated into greater gestational age (GA) (weeks) at delivery (35.1 [30.9-39.4] versus 28.1 [22.0-31.0], p = 0.0005). The 30-day survival of the affected recipient twin was improved (100% versus 57.1%, p = 0.0361). After multivariate testing, GA < 20 weeks at the time of the amniopatch placement was the only variable that remained associated with successful sealing of the membranes.

CONCLUSIONS:

Treatment of iPPROM via amniopatch was successful in almost two-thirds of cases and was associated with higher GA at delivery and improved perinatal survival.

KEYWORDS:

Fetal membrane patch; amniopatch; fetal membrane repair; fetal membrane sealant

PMID:
27686840
DOI:
10.1080/14767058.2016.1214123
[Indexed for MEDLINE]

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