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Am J Clin Pathol. 2016 Oct;146(4):496-502. doi: 10.1093/ajcp/aqw134.

Stromal PD-L1 Expression Is Associated With Better Disease-Free Survival in Triple-Negative Breast Cancer.

Author information

1
From the Department of Pathology and Laboratory Medicine, xli40@emory.edu.
2
Department of Biology, Georgia State University, Atlanta.
3
From the Department of Pathology and Laboratory Medicine.
4
Department of Biostatistics.
5
Morehouse College, Atlanta, GA.
6
Department of Surgery, and.
7
Department of Hematology and Medical Oncology, Emory University, Atlanta, GA.

Abstract

OBJECTIVES:

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, and there is no approved targeted therapy. We studied the expression of programmed cell death protein 1 (PD-1) and its ligand (PD-L1) in TNBC.

METHODS:

Full-face sections from 136 TNBC cases without neoadjuvant therapy between 2004 and 2013 were stained and evaluated for immune cell PD-1 staining and stromal or tumoral PD-L1 staining using the H-score (staining percentage × intensity). Nottingham histologic grade, lymphovascular invasion (LVI), mitotic count, and tumor-infiltrating lymphocytes (TILs) were evaluated. Tumor size, lymph node status, Ki-67 score, metastasis, overall survival (OS), and disease-free survival (DFS) were retrieved from medical records.

RESULTS:

Of the 136 TNBC cases, 69 (51%) had any PD-L1 staining and 35 (26%) had PD-L1 staining with an H-score of 5 or more; 117 (86%) had any PD-1 staining and 68 (50%) had PD-1 staining with an H-score of 5 or more. Tumor size and LVI were significantly associated with worse OS and DFS, and TILs and LVI were significantly associated with metastasis in univariate analysis. Stromal PD-L1 expression was significantly associated with better DFS in multivariate analysis. PD-1 expression was not associated with DFS, OS, or metastasis.

CONCLUSIONS:

PD-L1 expression is seen in a high proportion of TNBCs and associated with better DFS.

KEYWORDS:

Breast cancer; Disease-free survival; Full-face section; Overall survival; PD-1; PD-L1; Stromal PD-L1 expression; TNBC

PMID:
27686176
DOI:
10.1093/ajcp/aqw134
[Indexed for MEDLINE]

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