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Cell Death Dis. 2016 Sep 29;7(9):e2389. doi: 10.1038/cddis.2016.272.

Long noncoding RNAs in the progression, metastasis, and prognosis of osteosarcoma.

Author information

1
Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming 650118, China.

Abstract

Long noncoding RNAs (lncRNAs) are a class of non-protein-coding molecules longer than 200 nucleotides that are involved in the development and progression of many types of tumors. Numerous lncRNAs regulate cell proliferation, metastasis, and chemotherapeutic drug resistance. Osteosarcoma is one of the main bone tumor subtypes that poses a serious threat to adolescent health. We summarized how lncRNAs regulate osteosarcoma progression, invasion, and drug resistance, as well as how lncRNAs can function as biomarkers or independent prognostic indicators with respect to osteosarcoma therapy.

PMID:
27685633
PMCID:
PMC5059871
DOI:
10.1038/cddis.2016.272
[Indexed for MEDLINE]
Free PMC Article

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