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Arch Pathol Lab Med. 2016 Oct;140(10):1153-6. doi: 10.5858/arpa.2015-0492-RS.

Infantile Digital Fibroma: A Rare Fibromatosis.

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From the Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.


Infantile digital fibroma is a rare benign lesion that usually occurs during the first 2 years of life. It can be multiple, but it is usually a single lesion. If it grows large enough it can cause joint deformities or interfere with everyday activities. Microscopically, the neoplastic cells usually have inclusion bodies that are best highlighted with a Masson trichrome stain but can often be seen on hematoxylin-eosin staining. Treatment for this entity is usually watchful waiting because of its ability to spontaneously regress, but excision is recommended if the lesion is symptomatic. More recently, fluorouracil or injectable steroids have shown great promise in inducing regression without the complications that accompany surgery.

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