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J Appl Toxicol. 2017 May;37(5):554-562. doi: 10.1002/jat.3389. Epub 2016 Sep 29.

Association between perfluorooctanoic acid exposure and degranulation of mast cells in allergic inflammation.

Author information

CMRI, Departments of Pharmacology, Kyungpook National University, Daegu, Republic of Korea.
Natural Product Research Center, Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea.
Molecular Medicine, Kyungpook National University, Daegu, Republic of Korea.
Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
School of Life Science, Kyungpook National University, Daegu, Republic of Korea.
Department of Immunology, School of Medicine, Keimyung University, Daegu, Republic of Korea.
College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
College of Pharmacy, Woosuk University, Jeonju, Republic of Korea.
Department of Physiology, School of Medicine, Gachon University, Incheon, Republic of Korea.


Perfluorooctanoic acid (PFOA) has wide applications, including as a raw material for converted paper and packaging products. With the widespread use of PFOA, concerns regarding its potential environmental and health impacts have increased. In spite of the known hepatotoxicity and genotoxicity of PFOA, correlation with PFOA and allergic inflammation is not well known. In this study, the effect of PFOA on the degranulation of mast cells and mast cell-mediated allergic inflammation in the presence of FcεRI cross-linking was evaluated. In immunoglobulin (Ig) E-stimulated mast cells, PFOA increased the release of histamine and β-hexosaminidase by the up-regulation of intracellular calcium levels. PFOA enhanced gene expression of several pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 by the activation of nuclear factor (NF)-κB in IgE-stimulated mast cells. Also, PFOA exacerbated allergic symptoms via hypothermia, and an increase of serum histamine, TNF-α, IgE and IgG1 in the ovalbumin-induced systemic anaphylaxis. The present data indicate that PFOA aggravated FcɛRI-mediated mast cell degranulation and allergic symptoms.


allergic inflammation; histamine; mast cells; perfluorooctanoic acid (PFOA); pro-inflammatory cytokine

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