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Nat Genet. 2016 Sep 28;48(10):1105-6. doi: 10.1038/ng.3686.

Nucleosome mapping in plasma DNA predicts cancer gene expression.

Author information

1
Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, Arizona, USA, and the Mayo Clinic Center for Individualized Medicine, Scottsdale, Arizona, USA.
2
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK, and the Cambridge Cancer Centre, Department of Oncology, University of Cambridge, Cambridge, UK.

Abstract

A new study demonstrates that genomic sequencing coverage of plasma DNA fragments around transcription start sites reflects the expression levels of genes in corresponding tumors. This approach may enable noninvasive monitoring of treatment-induced changes in gene expression for patients with cancer.

PMID:
27681289
DOI:
10.1038/ng.3686
[Indexed for MEDLINE]

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