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Nat Genet. 2016 Sep 28;48(10):1102-3. doi: 10.1038/ng.3687.

A saltationist theory of cancer evolution.

Author information

1
University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, UK.

Abstract

A new study based on single-nucleus sequencing reports that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest stages of tumor evolution, rather than continuously and gradually, challenging prevailing models of tumor evolution.

PMID:
27681287
DOI:
10.1038/ng.3687
[Indexed for MEDLINE]

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