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Perit Dial Int. 2017 May-Jun;37(3):314-320. doi: 10.3747/pdi.2016.00129. Epub 2016 Sep 28.

Clinical Outcomes of Peritoneal Dialysis in End-Stage Renal Disease Patients with Liver Cirrhosis: A Propensity Score Matching Study.

Author information

1
Department of Internal Medicine, Dong-A University, Busan, Korea.
2
Department of Internal Medicine, Dong-A University, Busan, Korea anws@dau.ac.kr.

Abstract

♦ BACKGROUND: Clinical results of long-term peritoneal dialysis (PD) therapy in patients with liver cirrhosis (LC) and end-stage renal disease (ESRD) are controversial. This study evaluated the clinical outcomes of LC patients undergoing PD. ♦ METHODS: Clinical records were retrospectively collected from a single center between January 2007 and December 2014. An analysis of PD patients with LC and without liver disease was performed using propensity score matching. We further restricted matching by age, gender, and the presence of diabetes mellitus. Two cohorts of 33 patients each were selected. Early technical complications were defined as the presence of catheter-related complications, including malposition, leakage, omental wrapping, obstruction, and requiring a transfer to hemodialysis (HD) within 6 months of initiating PD. ♦ RESULTS: Mean PD duration was lower in LC patients (57.2 ± 46.1 months) than in controls (85.8 ± 64.2 months). Blood urea nitrogen, creatinine, and albumin levels were significantly lower in LC patients than in the control group. Cystatin C and cystatin C-based glomerular filtration rates were not significantly different in the LC group compared with those in the controls. We found that the risks for early technical complications, peritonitis, and long-term PD and patient survival were not higher in patients with LC than in those without LC. Ascites were easily controlled, and hepatic encephalopathy did not affect PD maintenance in LC patients. ♦ CONCLUSIONS: The clinical outcomes, including technical complications, peritonitis, and patients' survival, suggest that PD can be used as a renal replacement therapy in ESRD patients with LC.

KEYWORDS:

Peritoneal dialysis; liver cirrhosis; peritonitis; survival; technical complication

PMID:
27680763
DOI:
10.3747/pdi.2016.00129
[Indexed for MEDLINE]

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