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Rev Inst Med Trop Sao Paulo. 2016 Sep 22;58:73. doi: 10.1590/S1678-9946201658073.

SILVER NANOPARTICLES-DISK DIFFUSION TEST AGAINST Escherichia coli ISOLATES.

Author information

1
Universidade Federal do Ceará-UFC, Departamento de Química Analítica e Físico-Química Grupo de Química de Materiais Avançados(GQMAT). Campus do Pici, CP 12100, 60451-970 Fortaleza, CE, Brazil. E-mails: afraniocunha7@gmail.com; maome@superig.com.br; aubersonfarmaufc@gmail.com; pbafechine@gmail.com.
2
Universidade Federal do Ceará-UFC, Departamento de Análises Clínicas, Laboratório de Microbiologia de Leveduras. Fortaleza, CE, Brazil. E-mails: afraniocunha70@gmail.com; cecinhya@gmail.com; aubersonfarmaufc@gmail.com; microufc@gmail.com; iedaufc@gmail.com; menezes@ufc.br.

Abstract

Nanotechnology can be a valuable ally in the treatment of infections. Silver nanoparticles (AgNPs) are structures that have antimicrobial activity. The aim of this study was to produce AgNPs by green methods, characterize these structures, and assess their antimicrobial activity against Escherichia coli associated with the antibiotic ciprofloxacin. AgNPs were characterized by spectroscopic and microscopic techniques. Antimicrobial activity was evaluated by the disk diffusion method against 10 strains of E. coli. The synthesized AgNPs showed a spherical shape and a size of 85.07 ± 12.86 nm (mean ± SD). AgNPs increased the activity of ciprofloxacin by 40% and may represent a new therapeutic option for the treatment of bacterial infections.

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