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Macromol Biosci. 2017 Mar;17(3). doi: 10.1002/mabi.201600297. Epub 2016 Sep 29.

Structure-Function Correlations of Poly(Amido Amine)s for Gene Delivery.

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School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Department of Basic Pharmaceutical Sciences, School of Pharmacy, Husson University, Bangor, ME 04401-2929, USA.
Department of Microbiology and Cell Biology, School of life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China.


Poly(amido amine)s' (PAAs) versatility are nearly unique among stepwise polymers. Different functional groups can be easily introduced into these polymers to add functionality such as cell internalization, charge-shift, bioreducibility, "stealth" properties, and targeting moieties, while maintaining the bulk structural integrity of these polymers. The poly(amido amine)s are used as a unique research platform to elucidate their complex structure-function relationship. It is shown that guanidinium group, carboxyl group, disulfide bond, alkyl chain, branching, acetyl groups, benzoyl groups, and quaternary nicotinamide moieties can influence many steps of gene delivery, such as DNA condensation, cellular uptake, endosomal escape, nuclear entry, and finally gene expression. The authors systematically discuss the structure-function correlations of PAAs for gene delivery, and elaborate how the properties of polymers can be adjusted by changing the polymeric structure.


poly(amido amine)s; structure-function relationship; transfection efficiency

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