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Clin Kidney J. 2016 Oct;9(5):653-6. doi: 10.1093/ckj/sfw068. Epub 2016 Jul 28.

Atypical anti-glomerular basement membrane disease: lessons learned.

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David Geffen School of Medicine at UCLA , Laguna Niguel, Los Angeles, CA , USA.


Anti-glomerular basement membrane (GBM) disease usually pursues a self-limited course, at least from the immunological perspective. In addition, circulating antibodies to cryptic, conformational epitopes within the NC1 domain of the alpha 3 chain of Type IV Collagen are commonly found at the zenith of the clinical disease. However, exceptions to these general rules do occur, as exemplified by two remarkable cases reported in this issue of the Clinical Kidney Journal. The possible explanations for and the lessons learned from these uncommon occurrences are discussed in this short commentary.

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