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Nucleic Acids Res. 2017 Jan 4;45(D1):D466-D474. doi: 10.1093/nar/gkw857. Epub 2016 Sep 26.

Influenza Research Database: An integrated bioinformatics resource for influenza virus research.

Author information

1
J. Craig Venter Institute, La Jolla, CA 92037, USA.
2
Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, IA 50010, USA.
3
Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
4
Animal Health Service, Food and Agriculture Organization of the United Nations, Rome 00153, Italy.
5
Northrop Grumman Health Solutions, Rockville, MD 20850, USA.
6
Vecna Technologies, Greenbelt, MD 20770, USA.
7
Bioinformatics Institute, University of Auckland, Auckland 1010, New Zealand.
8
J. Craig Venter Institute, La Jolla, CA 92037, USA rscheuermann@jcvi.org.
9
Department of Pathology, University of California, San Diego, CA 92093, USA.
10
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

Abstract

The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support. Here, we describe the recent improvements in IRD including the use of cloud and high performance computing resources, analysis and visualization of user-provided sequence data with associated metadata, predictions of novel variant proteins, annotations of phenotype-associated sequence markers and their predicted phenotypic effects, hemagglutinin (HA) clade classifications, an automated tool for HA subtype numbering conversion, linkouts to disease event data and the addition of host factor and antiviral drug components. All data and tools are freely available without restriction from the IRD website at https://www.fludb.org.

PMID:
27679478
PMCID:
PMC5210613
DOI:
10.1093/nar/gkw857
[Indexed for MEDLINE]
Free PMC Article

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