Format

Send to

Choose Destination
J Clin Lipidol. 2016 Sep-Oct;10(5):1195-1202.e1. doi: 10.1016/j.jacl.2015.12.027. Epub 2016 Jan 6.

Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification.

Author information

1
Department of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address: mzaid@belle.shiga-med.ac.jp.
2
Department of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Shiga, Japan.
3
Department of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan.
4
Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Shiga, Japan.
5
Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
6
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
7
Division of Endocrinology and Metabolism, Department of Internal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
8
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
9
Department of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan; Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku University, Otsu City, Shiga, Japan.
10
Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan.

Abstract

BACKGROUND:

Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C).

OBJECTIVES:

Whether LDL-P is associated with subclinical atherosclerosis, independent of LDL-C, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis.

METHODS:

We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; >0 Agatston score) were examined.

RESULTS:

LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. Although these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made.

CONCLUSIONS:

In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P.

KEYWORDS:

Carotid intima-media thickness (cIMT); Coronary artery calcification (CAC); Low-density lipoprotein cholesterol (LDL-C); Low-density lipoprotein particle (LDL-P); Subclinical atherosclerosis

PMID:
27678437
PMCID:
PMC5047009
DOI:
10.1016/j.jacl.2015.12.027
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center